Antibiotic therapeutic options for infections caused by drug-resistant Gram-positive cocci

Antibiotic therapeutic options for infections caused by drug-resistant Gram-positive cocci.

Serious infections caused by Gram-positive bacteria are currently difficult to treat because many of these pathogens are now resistant to standard antimicrobial agents. As a result of the emergence and spread of multidrug-resistant Gram-positive pathogens, new antimicrobial agents are urgently needed for clinical use. In recent years, there has been an increase in the number of drugs that have ...

Bacterial Infections: Gram-Positive Cocci

Bacterial Infections: Gram-Positive Cocci

Emerging issues in the diagnosis and management of infections caused by multi-drug-resistant, gram-positive cocci.

BACKGROUND Rising rates of multi-drug-resistant, gram-positive cocci (e.g., methicillin-resistant Staphylococcus aureus [MRSA], vancomycin-resistant Enterococcus spp. [VRE]) have created treatment challenges for clinicians in both the hospital and community settings. These organisms have become especially problematic for hospitalized patients with pneumonia, complicated intra-abdominal infectio...

Management of infections caused by vancomycin-resistant gram-positive bacteria.

For 3 decades, vancomycin has been a favored therapy for serious penicillinand cephalosporin-resistant Gram-positive bacterial infections. Development of vancomycin resistance may have been restrained by the requirement for intravenous administration, which limited its use and lessened exposure to the gastrointestinal flora. Nevertheless, physicians are increasingly encountering children and ad...